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Micheal Jackson Over Dose??
Dr Shafer dismissed the idea the star could have drugged himself - an early argument put forward by the defence - as "crazy".
Dr Murray denies the charges.
Dr Shafer also suggested Dr Murray gave Jackson larger doses of the powerful sedative than he told the police.
The expert, who helped write the guidance printed on every bottle of propofol, walked the jury through a number of possible scenarios in the hours leading up to Jackson's death during his testimony on Thursday.
The Columbia University professor said it was most likely that the star was on an IV propofol drip when he stopped breathing, but that Dr Conrad Murray was out of the room.
The propofol kept flowing as the star's lungs emptied and even after he was dead, Dr Shafer told the jury.
He also suggested Dr Murray gave Jackson 100ml of propofol, a larger amount than the 25ml Dr Murray claims he administered.
"This fits all of the data in this case and I am not aware of a single piece of data that is inconsistent with this explanation," Dr Shafer told the court.
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